Psicoterapia e neuroscienze: il modello strategico ad orientamento neuroscientifico e il metodo mente - corpo

  • Mauro Cozzolino
  • Giovanna Celia

Abstract

In this paper we illustrate an innovative and effective model called Neuroscientific Strategic Psychotherapy. This model originates from the combination of integrative-strategic and psychosocial and cultural genomics approaches in psychotherapy.  From a holistic perspective of human functioning, we integrated modern neuroscientific findings in psychotherapy and genomics thus developing a therapeutic protocol called the Mind-Body Transformations Therapy.  We also developed an interdisciplinary research method that aims to investigate the translational mechanisms which have shown interesting connections between mind-body interventions and the immune system.  Mind-body interventions have proven to be effective in reducing the expression of pro-inflammatory genes associated with stress.  In line with these studies, our research team has explored the genomic-molecular basis of our protocol by means of bioinformatic software and DNA microarray.  After a single session of Mind-Body Transformations Therapy, we found patterns of experience-dependent gene expression that are associated with stem cell activation, and a reduction of inflammation, cell stress and epigenetic variations.  Along this line of research, we are implementing the Psychosocial Genomics Research Program in Oncology.  This program aims to evaluate the effects of the Mind-Body Transformations Therapy on cancer patients.  Through the study of human genome, we also aim to understand the mechanisms underlying the therapeutic effectiveness of our protocol.  From the clinical and empirical results we have obtained so far, we can state that combining strategic psychotherapy with neuroscientific findings has allowed us to develop an evidence-based model that facilitates mind-body healing and helps the treatment of several mental and psychosomatic conditions.

 Keywords: psychosocial genomics, Mind-Body Transformations Therapy, neuroscience

Abstract in italiano

Questo articolo presenta un modello psicoterapeutico innovativo ed efficace denominato Psicoterapia strategica a orientamento neuroscientifico, che nasce dal connubio fra la prospettiva strategica integrata in psicoterapia e l’approccio della Genomica Psicosociale e Culturale. In una prospettiva olistica del funzionamento dell’individuo, abbiamo integrato le più moderne conoscenze nel campo neuroscientifico, della psicoterapia e della genomica, sviluppando un approccio terapeutico denominato Mind-Body Transformations Therapy (MBT-T) ed un metodo di ricerca interdisciplinare finalizzato a indagare i meccanismi traslazionali connessi alla guarigione mente-corpo-geni. Di recente, vari studi di genomica funzionale hanno mostrato interessanti connessioni fra gli interventi mente-corpo e il sistema immunitario, evidenziando come queste terapie siano in grado di ridurre l’espressione dei geni pro-infiammatori associati allo stress. In linea con questi studi, il nostro team di ricerca ha utilizzato software bioinformatici e il DNA microarray per esplorare le basi genomico-molecolari del nostro protocollo (MBT-T). In risposta a una sola sessione di MBT-T, abbiamo riscontrato pattern di espressione genica esperienza-dipendenti associati all’attivazione di cellule staminali, riduzione dell’infiammazione, dello stress cellulare e variazioni di tipo epigenetico. In questa prospettiva, stiamo implementando il programma Psychosocial Genomics Research Program in Oncology (PSGPO) al fine di valutare i possibili effetti che il trattamento MBT-T può avere sui pazienti oncologici. Ci prefiggiamo di valutare la potenziale efficacia clinica di questo metodo terapeutico mente-corpo e di comprendere i meccanismi sottostanti il suo possibile effetto terapeutico attraverso lo studio del genoma. Grazie ai risultati clinici ed empirici finora ottenuti, possiamo affermare che aggiornare in chiave neuroscientifica la psicoterapia strategica sta consentendo lo sviluppo di un modello evidence-based che facilita la guarigione mente-corpo, contrastando in maniera efficace diversi disturbi sia all’interno del contesto della salute mentale sia in campo psicosomatico.

Parole Chiave: genomica psicosociale, Mind-Body Transformations Therapy, neuroscienze

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Pubblicato
2020-05-23
Come citare
Cozzolino, M., & Celia, G. (2020). Psicoterapia e neuroscienze: il modello strategico ad orientamento neuroscientifico e il metodo mente - corpo. Phenomena Journal - Giornale Internazionale Di Psicopatologia, Neuroscienze E Psicoterapia, 2(1), 89 -101. https://doi.org/10.32069/pj.2020.1.22
Sezione
Ricerca originale